SCREENING OF THE EFFECTS OF PLANT ALKALOIDS ON THE CONTRACTILE ACTIVITY OF RAT TRACHEAL SMOOTH MUSCLE CELLS

Authors

  • Begdullaeva G. S. Karakalpak State university named after Berdakh,
  • Qoshanov D. Е. Nukus branch of the Uzbek State university of Physical Training and Sports

Keywords:

plant alkaloids, relaxant action, antispasmodic action, smooth muscle cells

Abstract

The article studies the effect of plant alkaloids 1-O-benzoylnapellin, zongorin, dihydroathysine and 6-benzoylheterathisine on the contractile activity of rat tracheal smooth muscle cells. It was found that 1-O-benzoylnapellin, dihydratizine, 6-benzoylheterazine and zongorin under conditions of КСl -induced contracture exhibit a relaxant effect, which may be due to their interaction with potential-dependent Са2+ channels of plasma membranes and suppression of the entry of Са2+ ions into the MMC of rat trachea.

Downloads

Published

2023-01-17

How to Cite

Begdullaeva G. S., & Qoshanov D. Е. (2023). SCREENING OF THE EFFECTS OF PLANT ALKALOIDS ON THE CONTRACTILE ACTIVITY OF RAT TRACHEAL SMOOTH MUSCLE CELLS. British Journal of Global Ecology and Sustainable Development, 12, 55–57. Retrieved from https://journalzone.org/index.php/bjgesd/article/view/207

Issue

Vol. 12 (2023)

Section

Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

You are free to:

  1. Share — copy and redistribute the material in any medium or format
  2. The licensor cannot revoke these freedoms as long as you follow the license terms.

Under the following terms:

  1. Attribution — You must give appropriate credit , provide a link to the license, and indicate if changes were made . You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
  2. NonCommercial — You may not use the material for commercial purposes .
  3. NoDerivatives — If you remix, transform, or build upon the material, you may not distribute the modified material.
  4. No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits